Designing organizations adapted to uncertainty work is strategically important. This issue talks about 3 aspects of organizational design for uncertainty work: 1) Uncertainty work ≠ risk work. Uncertainty work (new product development, R&D, innovation, new business models) requires a fundamentally different approach to organizational design; 2) Mundane organizational processes literally shape organizations by shaping everyday organizational life; 3) Appropriate organizational technology requires redesigning these mundane organizational processes to explicitly acknowledge uncertainty.